Conference Day Two
Friday December 13, 2024

8:00 am Check-In & Coffee

8:50 am Chair’s Opening Remarks

Clarifying Regulators Expectations & Criteria to Accelerate IND Approvals to Drive Pipelines Forward

9:00 am Focusing on Regulatory Obstacles Which Could Potentially Limit Translation into the Clinic

  • Ana Sousa Chief Regulatory Officer & Senior Vice President - Global Regulatory Affairs, Quality & Product Strategy, Aspen Neuroscience

Synopsis

  • Understanding the criteria set for applications to be approved to move forward into the clinic
  • Looking into case studies and experiences of therapies currently in the clinic to gain insights into negotiations with regulatory bodies
  • Planning for future applications to gain approval first time

Showcasing Groundbreaking Preclinical & Clinical Data in Various Indications

9:30 am Exploring New Data & Addressing Challenges in Treating Parkinson’s Disease (PD) Using Cell Therapies

Synopsis

  • Discussing different origins of PD (idiopathic/genetic causes) to understand the scope of the disease
  • Considering which forms of PD would be most suited to being treated with cell therapies
  • Presenting promising data showing improved outcomes for patients with PD treated with cell therapies

10:00 am Driving Pipelines for Alzheimer’s Disease (AD) & Parkinson’s Disease (PD): Unleashing the Potential of NK Cell Therapies for Neurodegenerative Diseases

  • Paul Song Chief Executive Officer & Chairman, NKGen Biotech

Synopsis

  • Navigating the need novel cell therapies in comparison to other forms of treatment for AD and PD
  • Exploring the newest NK cell therapy data in AD to reveal positive results discovered thus far
  • Planning for the future of NK cell therapies in neurodegenerative diseases to suggest directions for these indications

10:30 am Morning Break & Networking

11:00 am Discussing Progress & Newest Data in Cell Therapies Treating Epilepsy to Showcase Promise for Patients

  • Yves Maury Director, Discovery Department, Neurona Therapeutics

Synopsis

  • Development of a pluripotent stem cell-derived cell therapy product for the treatment of focal epilepsy
  • Evaluation in preclinical animal models
  • Emerging clinical data from ongoing clinical trials
  • Understanding challenges in the democratization of cell therapies for CNS

11:30 am Coya 302: A Dual Mechanism Potential Biological Immunotherapy for ALS and FTD

  • Fred Grossman President & Chief Medical Officer, Coya Therapeutics

Synopsis

  • Treg dysfunction as a core driver of neurodegeneration in ALS and FTD
  • Coya 302 targets adaptive and innate immune pathways
  • Coya 302 as potential therapy for ALS and FTD

12:00 pm CAR-T: The next frontier in Multiple Sclerosis & other Demyelinating Diseases

  • Burhan Chaudhry Director, Early Clinical Development, Bristol Myers Squibb

Synopsis

  • Science behind CAR-T in Autoimmune Neurological Diseases
  • Clinical data so far in CNS Demyelinating Diseases
  • What the future holds

12:30 pm Lunch Break & Networking

1:30 pm Delving into Cell Therapy for Spinal Cord Injury (SCI)

Synopsis

  • Navigating data showing the potential of cell therapies in SCI to highlight the scope of treatment
  • Learning about the forms of SCI that cell therapies are involved in treating
  • Considering which types of SCI cell therapies could treat in the future

2:00 pm Panel Discussion: Choosing Targets in Diseases with Multiple Causes & Affected Areas & Considering Accessibility

  • Jacob Koffler Assistant professor of Neurosciences, UCSD
  • Brian Culley Chief Executive Officer, Lineage Cell Therapeutics Inc.

Synopsis

  • Deciding on what criteria (market gap, potential etc) should be used to select treatment area
  • Unravelling the challenges in developing therapeutics for disorders with a wide variety of potential origins
  • Discussing patient perspective and accessibility for treatments

2:30 pm Afternoon Break & Networking

Rationalizing Target Indications & Discussing Motivations Behind Developing Cell Therapies for Specific Indications

3:00 pm Examining Future Potential Indications of Cell Therapies for Neurological Disorders

Synopsis

  • Discovering the next potential neurological indications where cell therapies could be utilized in neurological disorders such as pain, autism, etc
  • Reviewing the literature to understand how efficacious cell therapies could be in these areas
  • Unravelling the challenges associated with these different indications

3:30 pm Panel Discussion: Exploring the ‘Low Hanging Fruit’ Indications & Choosing Specific Target Indications

  • Jim Musick CSO and Director, Vitro Biopharma
  • Igor Lavrov Assistant Professor - Neurology & Biomedical Engineering, Mayo Clinic

Synopsis

  • Which indications are expected to be the first to accelerate through the clinic?
  • Which indications have the most funding associated with them?

4:00 pm Chair’s Closing Remarks

4:10 pm End of Conference Day Two & Close of Conference